Problem:

Unable to install the latest build of Windows 10 when DESlock+ Full Disk Encryption (FDE) is enabled on the System Disk.

When installing it brings up an error stating:
Disable encryption to continue or run windows setup with the /reflectdrivers command-line option

Background:

As Security is a big portion of what I do, I have both my Work and Home Windows 10 machines Encrypted with FDE. Its definitely overkill for my home PC but it serves a purpose on my work machine. I can sleep happily knowing that if the machine is ever stolen – They’re not getting to my data. It’s probably also worth mentioning that I recommend having FDE in place for businesses.

Resolution:

I used the following article to get round it:
https://support.deslock.com/index.php?/Default/Knowledgebase/Article/View/379

You need to Download the Media Creation tool, save an ISO and then install the DESlock+Win10Update utility:
https://support.deslock.com/resources/KB379/DESlock+Win10Updater.exe

When the Utility Runs, you need to point it at the mounted Win10 ISO. It will then complete the upgrade as normal.